Article
The nuclear receptor transcription factor, retinoid-related orphan receptor beta, regulates retinal progenitor proliferation.
Mechanisms of development - 1 Oct 1998
Chow L, Levine E M, Reh T A
Abstract excerpt
We examined the role of retinoid-related orphan receptor (ROR)beta, a member of the nuclear receptor family of transcription factors, in retinal neurogenesis. In situ hybridization studies showed that RORbeta is expressed in retinal progenitor cells in the embryonic rat retina. Further studies de...
Topics
- Animals
- Cell Division
- Down-Regulation
- Eye Abnormalities
- Gene Expression Regulation, Developmental
- Homeodomain Proteins
- Mice
- Mice, Mutant Strains
- Mutation
- Nuclear Receptor Subfamily 1, Group F, Member 2
- Rats
- Receptors, Cell Surface
- Receptors, Cytoplasmic and Nuclear
- Retina
- Stem Cells
- Transcription Factors