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Article

Targeted Ablation of Crb1 and Crb2 in Retinal Progenitor Cells Mimics Leber Congenital Amaurosis

5 Dec 2013

Abstract excerpt

Development in the central nervous system is highly dependent on the regulation of the switch from progenitor cell proliferation to differentiation, but the molecular and cellular events controlling this process remain poorly understood. Here, we report that ablation of Crb1 and Crb2 genes results in severe impairment of retinal function, abnormal lamination and thickening of the retina mimicking human Leber...

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PMID: 24339791
DOI: 10.1371/journal.pgen.1003976

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Targeted Ablation of Crb1 and Crb2 in Retinal Progenitor Cells Mimics Leber Congenital AmaurosisPMID 24339791Read ↗

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