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Article

Prdm1 overexpression causes a photoreceptor fate-shift in nascent, but not mature, bipolar cells.

Developmental biology - 15 Aug 2020

Goodson Noah B, Park Ko U, Silver Jason S, Chiodo Vince A, Hauswirth William W, Brzezinski Joseph A

Abstract excerpt

The transcription factors Prdm1 (Blimp1) and Vsx2 (Chx10) work downstream of Otx2 to regulate photoreceptor and bipolar cell fates in the developing retina. Mice that lack Vsx2 fail to form bipolar cells while Prdm1 mutants form excess bipolars at the direct expense of photoreceptors. Excess bipolars in Prdm1 mutants appear to derive from rods, suggesting that photoreceptor fate remains mutable for some time...

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Share to Cellular Reprogramming
Share to Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homeodomain Proteins

Share to Mice, Transgenic

Share to Otx Transcription Factors

Share to Photoreceptor Cells, Vertebrate

Share to Positive Regulatory Domain I-Binding Factor 1

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Source

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Identifiers

PMID: 32562755
DOI: 10.1016/j.ydbio.2020.06.003
PMCID: PMC7386070

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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