Article
A role for the small GTPase Rac in polyomavirus middle-T antigen-mediated activation of the serum response element and in cell transformation.
Oncogene - 13 Mar 1997
Urich M, Senften M, Shaw P E, Ballmer-Hofer K
Abstract excerpt
The oncogenic proteins encoded by papovaviruses, the tumor antigens, have been extensively used as model systems to study mitogenic signaling and cell transformation. These proteins stimulate cell growth in cultured cells and induce tumors in virus infected or transgenic animals. One of these pro...
Topics
- 3T3 Cells
- Alleles
- Animals
- Antigens, Polyomavirus Transforming
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Cycle Proteins
- Cell Transformation, Viral
- DNA-Binding Proteins
- Fibroblasts
- GTP-Binding Proteins
- Mice
- Microinjections
- Mitogen-Activated Protein Kinase 3
- Mitogen-Activated Protein Kinases
- Nuclear Proteins
- Promoter Regions, Genetic
- Rats
- Rats, Inbred F344