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Article

Transformation and tumorigenic properties of a mutant polyomavirus containing a middle T antigen defective in Shc binding.

Journal of virology - 1 Sept 1997

Yi X, Peterson J, Freund R

Abstract excerpt

Polyomavirus middle T antigen is phosphorylated on several tyrosine residues which act as binding sites for cellular proteins, including phosphatidylinositol 3-kinase, Shc, and phospholipase C-gamma. In this report we describe the transforming properties and tumor-inducing ability of a polyomavirus that contains a single-site mutation in middle T antigen which changes a tyrosine residue at amino acid position 250...

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Identifiers

PMID: 9261344
DOI: 10.1128/JVI.71.9.6279-6286.1997
PMCID: PMC191900

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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