Article
Rapid analysis of XRCC1 polymorphisms using real-time polymerase chain reaction.
Molecular and cellular probes - 1 Jan 2000
Schneider Joachim, Classen Vera, Philipp Monika, Helmig Simone
Abstract excerpt
DNA repair plays a critical role in protecting the genome from carcinogens or ionizing radiation. Three coding polymorphisms at codons 194, 280, and 399 in X-ray cross-complementing group 1 (XRCC1) DNA repair gene have been identified that may affect DNA repair and alter cancer susceptibility. In order to study their role in molecular-epidemiology studies we developed a single-step procedure for genotyping these...
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