Article
Polymorphisms of the XRCC1 DNA repair gene in head and neck cancer.
Pathology oncology research : POR - 1 Jan 2005
Demokan Semra, Demir Deniz, Suoglu Yusufhan, Kiyak Erkan, Akar Ugur, Dalay Nejat
Abstract excerpt
Inherited polymorphisms in the genes controlling the cell cycle or functioning in the DNA repair mechanisms may impair their function and contribute to genetic susceptibility. Abnormalities in the DNA repair have been reported in head and neck cancer. The XRCC1 gene functions in singlestrand break and base excision repair processes. In this study, two polymorphisms of the XRCC1 gene, Arg194Trp and Arg399Gln were...
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