Article
Inheritance of the 194Trp and the 399Gln variant alleles of the DNA repair gene XRCC1 are associated with increased risk of early-onset colorectal carcinoma in Egypt.
Cancer letters - 16 Oct 2000
Abdel-Rahman S Z, Soliman A S, Bondy M L, Omar S, El-Badawy S A, Khaled H M, Seifeldin I A, Levin B
Abstract excerpt
Patients under age 40 constitute 35.6% of all colorectal cancer cases in Egypt, an unusual disease pattern to which both environmental exposures and inefficient DNA repair may contribute. While a number of polymorphisms in DNA repair genes have been recently identified, their role as cancer risk...
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