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Article

From genotype to phenotype: correlating XRCC1 polymorphisms with mutagen sensitivity.

DNA repair - 12 Aug 2003

Wang Yunfei, Spitz Margaret R, Zhu Yong, Dong Qiong, Shete Sanjay, Wu Xifeng

Abstract excerpt

This study correlated the extent of induced in vitro chromosomal damage, assessed by the mutagen sensitivity assay, with genotypes of the X-ray repair cross complementing group 1 (XRCC1) gene, which encodes for a base excision repair protein. There are two common polymorphisms that cause amino acid substitutions in XRCC1, one at codon 194 in exon 6 and another at codon 399 in exon 10. We genotyped these two...

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Source

Identifiers

PMID: 12893086
DOI: 10.1016/s1568-7864(03)00085-5

Genes

XRCC1
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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