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Article

Multiplex pyrosequencing of two polymorphisms in DNA repair gene XRCC1.

The Journal of molecular diagnostics : JMD - 1 Sept 2006

van der Straaten Tahar, Kweekel Dinemarie, Tiller Marco, Bogaartz Judith, Guchelaar Henk-Jan

Abstract excerpt

DNA repair enzymes play a pivotal role in platinum-based chemotherapy. Within the gene encoding for the base excision repair enzyme XRCC1, several nonsynonymous polymorphisms have been identified. It has been shown that the Arg399Gln single-nucleotide polymorphism results in a polymorphic enzyme that is less capable of initiating DNA repair. We developed a multiplex pyrosequence assay to simultaneously detect two...

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Source

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Identifiers

PMID: 16931584
DOI: 10.2353/jmoldx.2006.060018
PMCID: PMC1867628

Genes

XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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