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Article

Polymorphisms in the DNA repair genes XRCC1 and ERCC2 and biomarkers of DNA damage in human blood mononuclear cells.

Carcinogenesis - 1 May 2000

Duell E J, Wiencke J K, Cheng T J, Varkonyi A, Zuo Z F, Ashok T D, Mark E J, Wain J C, Christiani D C, Kelsey K T

Abstract excerpt

Polymorphisms in several DNA repair genes have recently been identified, but little is known about their phenotypic significance. To determine whether variation in DNA repair genes is related to host DNA damage, we studied the association between polymorphisms in XRCC1 (codon 399) and ERCC2 (codon 751) and two markers of DNA damage, sister chromatid exchange (SCE) frequencies (n = 76) and polyphenol DNA adducts...

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Source

Identifiers

PMID: 10783319
DOI: 10.1093/carcin/21.5.965

Genes

XRCC1
ERCC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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