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Article

Serotonin transporter polymorphism mediates vulnerability to loss of incentive motivation following acute tryptophan depletion.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Oct 2006

Roiser Jonathan P, Blackwell Andrew D, Cools Roshan, Clark Luke, Rubinsztein David C, Robbins Trevor W, Sahakian Barbara J

Abstract excerpt

The serotonin (5-HT) system is implicated in incentive motivational processes. The present study utilized the acute tryptophan depletion (ATD) procedure to investigate the effect of temporarily lowering 5-HT synthesis on motivation in healthy volunteers, stratifying the results by allelic variation at the serotonin transporter gene (5-HTTLPR). ATD resulted in a robust reduction in plasma tryptophan concentration....

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Identifiers

PMID: 16541086
DOI: 10.1038/sj.npp.1301055
PMCID: PMC1852058

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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