Interactive effects of sex and 5-HTTLPR on mood and impulsivity during tryptophan depletion in healthy people.

doi:10.1016/j.biopsych.2007.02.012

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Article

Interactive effects of sex and 5-HTTLPR on mood and impulsivity during tryptophan depletion in healthy people.

Biological psychiatry - 15 Sept 2007

Walderhaug Espen, Magnusson Andres, Neumeister Alexander, Lappalainen Jaakko, Lunde Hilde, Refsum Helge, Landrø Nils Inge

Abstract excerpt

BACKGROUND: Serotonin (5-HT) plays a central role in mood regulation and impulsivity. We studied whether healthy men and women react differently on mood and impulsivity measures during acute tryptophan depletion (ATD). We also studied the relative contribution of a functional length triallelic polymorphism in the promoter region of the serotonin transporter, designated 5-HTTLPR, to the behavioral responses to...

Topics

Adult
Affect
Depressive Disorder, Major
Double-Blind Method
Female
Genotype
Humans
Impulsive Behavior
Male
Mood Disorders
Norway

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Prevalence

Promoter Regions, Genetic

Serotonin

Serotonin Plasma Membrane Transport Proteins

Tryptophan

Source

Open in PubMed

Identifiers

PMID: 17544379
DOI: 10.1016/j.biopsych.2007.02.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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