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The short (S) allele of the serotonin transporter polymorphism and acute tryptophan depletion both increase impulsivity in men.

Neuroscience letters - 12 Apr 2010

Walderhaug Espen, Herman Aryeh Isaac, Magnusson Andres, Morgan Michael John, Landrø Nils Inge

Abstract excerpt

Reduced serotonergic neurotransmission is implicated in impulsive behavior. We studied the triallelic system of the serotonin transporter gene linked polymorphic region (5-HTTLPR) and acute manipulation of serotonin together to further delineate the mechanisms by which serotonergic neurotransmission affects impulsivity. Fifty-two healthy participants (38 men and 14 women) underwent acute tryptophan depletion...

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Alleles
Double-Blind Method
Impulsive Behavior
Polymorphism, Genetic
Serotonin Plasma Membrane Transport Proteins

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PMID: 20188795
DOI: 10.1016/j.neulet.2010.02.048
PMCID: PMC3662246

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