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Article

SLC6A4 polymorphisms modulate the efficacy of a tryptophan-enriched diet on age-related depression and social cognition.

Clinical nutrition (Edinburgh, Scotland) - 1 Apr 2021

Ugartemendia Lierni, Bravo Rafael, Reuter Martin, Castaño M Yolanda, Plieger Thomas, Zamoscik Vera, Kirsch Peter, Rodríguez Ana B

Abstract excerpt

BACKGROUND & AIMS: In a placebo controlled study we sought to determine if a four-weeks tryptophan-enriched diet is able to improve age-related depression or social cognitive impairment, depending on polymorphisms located in the promoter region of Solute Carrier Family 6 Member 4 (SLC6A4), also known as serotonin transporter (SERT1) gene. METHODS: 91 young volunteers (age: 21 ± 2 yrs) and 127 above 50 years old...

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Identifiers

PMID: 33743283
DOI: 10.1016/j.clnu.2021.02.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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