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Article

Differential effects of tri-allelic 5-HTTLPR polymorphisms in healthy subjects on mood and stress performance after tryptophan challenge.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Dec 2009

Markus C Rob, Firk Christine

Abstract excerpt

Earlier data suggest that a polymorphism at the serotonin (5-HT) transporter gene (5-HTTLPR) may affect depression particularly in the face of stress due to interactions between 5-HT vulnerability and stress exposure. However, this interaction between 5-HT transporter-linked transcriptional promoter region (5-HTTLPR), 5-HT vulnerability and the affective effects of stress exposure has not yet been investigated....

Topics

Affect
Alleles
Cross-Over Studies
Female
Genotype
Humans
Hydrocortisone
Male
Polymorphism, Genetic
Psychomotor Performance
Saliva

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Serotonin Plasma Membrane Transport Proteins

Stress, Physiological

Stress, Psychological

Tryptophan

Young Adult

Source

Identifiers

PMID: 19675533
DOI: 10.1038/npp.2009.92

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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