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Tryptophan Depletion, Serotonin, and Depression: Where Do We Stand?

12 Aug 2025

Abstract excerpt

Tryptophan depletion is a widely used paradigm to study serotonin system-related mechanisms in the pathophysiology and treatment of depression. There is convincing evidence that tryptophan depletion primarily and selectively affects serotonergic transmission. The behavioral data in healthy controls with and without genetic risk for depression, and in patient populations during the symptomatic phase of depression...

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PMID: 15131521
DOI: 10.64719/pb.4167

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