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HIV-1 Vpr degrades the HLTF DNA translocase in T cells and macrophages

25 Apr 2016

Abstract excerpt

Viruses often interfere with the DNA damage response to better replicate in their hosts. The human immunodeficiency virus 1 (HIV-1) viral protein R (Vpr) protein has been reported to modulate the activity of the DNA repair structure-specific endonuclease subunit (SLX4) complex and to promote cell cycle arrest. Vpr also interferes with the base-excision repair pathway by antagonizing the uracil DNA glycosylase...

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PMID: 27114546
DOI: 10.1073/pnas.1600485113

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