Article
Suppression of UV-induced apoptosis by the human DNA repair protein XPG.
Cell death and differentiation - 1 Mar 2006
Clément V, Dunand-Sauthier I, Clarkson S G
Abstract excerpt
The severe xeroderma pigmentosum/Cockayne syndrome (XP/CS) syndrome is caused by mutations in the XPB, XPD and XPG genes that encode the helicase subunits of TFIIH and the 3' endonuclease of nucleotide excision repair (NER). Because XPB and XPD have been implicated in p53-mediated apoptosis, we examined the possible involvement of XPG in this process. After ultraviolet light (UV) irradiation, primary fibroblasts...
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