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Article

Characterization of ERCC3 mutations in the Chinese hamster ovary 27-1, UV24 and MMC-2 cell lines.

Mutation research - 29 Jan 2006

Hall Hana, Gurský Ján, Nicodemou Andreas, Rybanská Ivana, Kimlícková Erika, Pirsel Miroslav

Abstract excerpt

Mutation of the XPB gene in humans gives rise to the distinct, autosomal recessive disorder, with a striking clinical heterogeneity: xeroderma pigmentosum associated with Cockayne's syndrome and trichothiodystrophy. XPB is a subunit of a multifunctional RNA polymerase II general initiation factor TFIIH and codes for 3'-->5' DNA helicase essential for both nucleotide excision repair (NER) and transcription. Since...

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Source

Identifiers

PMID: 16143348
DOI: 10.1016/j.mrfmmm.2005.07.013

Genes

ERCC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Characterization of ERCC3 mutations in the Chinese hamster ovary 27-1, UV24 and MMC-2 cell lines.PMID 16143348Read ↗

Newly identified CHO ERCC3/XPB mutations and phenotype characterization.Semantic proximity Read ↗

ERCC1 mutations in UV-sensitive Chinese hamster ovary (CHO) cell lines.Semantic proximity Read ↗

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Clinical heterogeneity within xeroderma pigmentosum associated with mutations in the DNA repair and transcription gene ERCC3.Semantic proximity Read ↗

Phenotype of FAECB (Facility for Automated Experiments in Cell Biology) Chinese hamster ovary mutants with minimal UV-sensitivity.Semantic proximity Read ↗

Common XPD (ERCC2) polymorphisms have no measurable effect on nucleotide excision repair and basal transcription.Semantic proximity Read ↗

Identification of ICR170-induced XPD mutations in UV-sensitive CHO cells.Semantic proximity Read ↗

Functional capacity of XRCC1 protein variants identified in DNA repair-deficient Chinese hamster ovary cell lines and the human populationSemantic proximity Read ↗

Every protagonist has a sidekick: Structural aspects of human xeroderma pigmentosum-binding proteins in nucleotide excision repair.Semantic proximity Read ↗

Cisplatin sensitivity/resistance in UV repair-deficient Chinese hamster ovary cells of complementation groups 1 and 3Semantic proximity Read ↗

First reported patient with human ERCC1 deficiency has cerebro-oculo-facio-skeletal syndrome with a mild defect in nucleotide excision repair and severe developmental failure.Semantic proximity Read ↗

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