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Article

A novel DDB2-ATM feedback loop regulates human cytomegalovirus replication.

Journal of virology - 1 Feb 2014

E Xiaofei, Savidis George, Chin Christopher R, Wang Shixia, Lu Shan, Brass Abraham L, Kowalik Timothy F

Abstract excerpt

Human cytomegalovirus (HCMV) genome replication requires host DNA damage responses (DDRs) and raises the possibility that DNA repair pathways may influence viral replication. We report here that a nucleotide excision repair (NER)-associated-factor is required for efficient HCMV DNA replication. Mutations in genes encoding NER factors are associated with xeroderma pigmentosum (XP). One of the XP complementation...

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Source

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Identifiers

PMID: 24335308
DOI: 10.1128/JVI.03423-13
PMCID: PMC3911552

Genes

DDB2
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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