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Article

Human XPF controls TRF2 and telomere length maintenance through distinctive mechanisms.

Mechanisms of ageing and development - 1 Oct 2008

Wu Yili, Mitchell Taylor R H, Zhu Xu-Dong

Abstract excerpt

XPF-ERCC1, a structure-specific endonuclease, is involved in nucleotide excision repair, crosslink repair and homologous recombination. XPF-ERCC1 is also found to interact with TRF2, a duplex telomeric DNA binding protein. We have previously shown that XPF-ERCC1 is required for TRF2-promoted telomere shortening. However, whether XPF-ERCC1 by itself has a role in telomere length maintenance has not been...

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Source

Identifiers

PMID: 18812185
DOI: 10.1016/j.mad.2008.08.004

Genes

ERCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Human XPF controls TRF2 and telomere length maintenance through distinctive mechanisms.PMID 18812185Read ↗

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TRF2 overexpression diminishes repair of telomeric single-strand breaks and accelerates telomere shortening in human fibroblastsSemantic proximity Read ↗

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