Article
Subunit stoichiometry and arrangement in a heteromeric glutamate-gated chloride channel.
Proceedings of the National Academy of Sciences of the United States of America - 2 Feb 2016
Degani-Katzav Nurit, Gortler Revital, Gorodetzki Lilach, Paas Yoav
Abstract excerpt
The invertebrate glutamate-gated chloride-selective receptors (GluClRs) are ion channels serving as targets for ivermectin (IVM), a broad-spectrum anthelmintic drug used to treat human parasitic diseases like river blindness and lymphatic filariasis. The native GluClR is a heteropentamer consisti...
Topics
- Animals
- Binding Sites
- CHO Cells
- Chloride Channels
- Cricetinae
- Cricetulus
- Mutation
- Patch-Clamp Techniques