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Article

Neuronal toxicity in Caenorhabditis elegans from an editing site mutant in glutamate receptor channels.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Sept 2004

Aronoff Rachel, Mellem Jerry E, Maricq Andres Villu, Sprengel Rolf, Seeburg Peter H

Abstract excerpt

Ionotropic glutamate receptors (iGluRs) in Caenorhabditis elegans are predicted to have high permeability for Ca2+ because of glutamine (Q) residues in the pore loop. This contrasts to the low Ca2+ permeability of similar iGluRs in principal neurons of mammals, because of an edited arginine (R) at the critical pore position in at least one channel subunit. Here, we introduced the R residue into the pore loop of a...

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Identifiers

PMID: 15371514
DOI: 10.1523/JNEUROSCI.2587-04.2004
PMCID: PMC6729790

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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