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Article

Functional evaluation of key interactions evident in the structure of the eukaryotic Cys-loop receptor GluCl.

ACS chemical biology - 17 Oct 2014

Daeffler Kristina N-M, Lester Henry A, Dougherty Dennis A

Abstract excerpt

The publication of the first high-resolution crystal structure of a eukaryotic Cys-loop receptor, GluClα, has provided valuable structural information on this important class of ligand-gated ion channels (LGIC). However, limited functional data exist for the GluCl receptors. Before applying the structural insights from GluCl to mammalian Cys-loop receptors such as nicotinic acetylcholine and GABA receptors, it is...

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Identifiers

PMID: 25051140
DOI: 10.1021/cb500323d
PMCID: PMC4201344

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Source receipt: pubmed, retrieved 7 Sept 2026.

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