Article
Two types of chloride transporters are required for GABA(A) receptor-mediated inhibition in C. elegans.
The EMBO journal - 4 May 2011
Bellemer Andrew, Hirata Taku, Romero Michael F, Koelle Michael R
Abstract excerpt
Chloride influx through GABA-gated Cl(-) channels, the principal mechanism for inhibiting neural activity in the brain, requires a Cl(-) gradient established in part by K(+)-Cl(-) cotransporters (KCCs). We screened for Caenorhabditis elegans mutants defective for inhibitory neurotransmission and identified mutations in ABTS-1, a Na(+)-driven Cl(-)-HCO(3)(-) exchanger that extrudes chloride from cells, like KCC-2,...
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