Article
The mechanical phenotype of biglycan-deficient mice is bone- and gender-specific.
Bone - 1 Jul 2006
Wallace Joseph M, Rajachar Rupak M, Chen Xiao-Dong, Shi Songtao, Allen Matthew R, Bloomfield Susan A, Les Clifford M, Robey Pamela G, Young Marian F, Kohn David H
Abstract excerpt
Biglycan (bgn) is a small leucine-rich proteoglycan (SLRP) enriched in the extracellular matrix of skeletal tissues. While bgn is known to be involved in the growth and differentiation of osteoblast precursor cells and regulation of collagen fibril formation, it is unclear how these functions impact bone's geometric and mechanical properties, properties which are integral to the structural function of bone....
Topics
- Animals
- Biglycan
- Biomechanical Phenomena
- Bone Density
- Bone and Bones
- Extracellular Matrix Proteins
- Female
- Male
- Mice
- Mice, Inbred C57BL
- Phenotype
- Proteoglycans
- Sex Factors
- Tomography, X-Ray Computed