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Article

Biglycan knockout mice: new models for musculoskeletal diseases.

Glycoconjugate journal - 1 Jan 2000

Young Marian F, Bi Yanming, Ameye Laurent, Chen Xiao-Dong

Abstract excerpt

Biglycan is a Class I Small Leucine Rich Proteoglycans (SLRP) that is localized on human chromosome Xq28-ter. The conserved nature of its intron-exon structure and protein coding sequence compared to decorin (another Class I SLRP) indicates the two genes may have arisen from gene duplication. Big...

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Source

Identifiers

PMID: 12975603
DOI: 10.1023/A:1025336114352

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12975603-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Biglycan knockout mice: new models for musculoskeletal diseases.PMID 12975603Read ↗

Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice.Semantic proximity Read ↗

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The mechanical phenotype of biglycan-deficient mice is bone- and gender-specific.Semantic proximity Read ↗

Phenotypic characterization of epiphycan-deficient and epiphycan/biglycan double-deficient mice.Semantic proximity Read ↗

Uterine dysfunction in biglycan and decorin deficient mice leads to dystocia during parturition.Semantic proximity Read ↗

A mouse model of spontaneous preterm birth based on the genetic ablation of biglycan and decorinSemantic proximity Read ↗

Biglycan Deficiency Causes Spontaneous Aortic Dissection and Rupture in MiceSemantic proximity Read ↗

Investigating the temporal roles of decorin and biglycan in tendon healingSemantic proximity Read ↗

Regulation of fibrillin-1 by biglycan and decorin is important for tissue preservation in the kidney during pressure-induced injury.Semantic proximity Read ↗

Human genetic disorders and knockout mice deficient in glycosaminoglycan.Semantic proximity Read ↗

Effects of biglycan deficiency on myocardial infarct structure and mechanics.Semantic proximity Read ↗

Mechanical, compositional, and structural properties of the mouse patellar tendon with changes in biglycan gene expression.Semantic proximity Read ↗

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