Article
Genetic variation in bone growth patterns defines adult mouse bone fragility.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Nov 2005
Price Christopher, Herman Brad C, Lufkin Thomas, Goldman Haviva M, Jepsen Karl J
Abstract excerpt
UNLABELLED: Femoral morphology and composition were determined for three inbred mouse strains between ages E18.5 and 1 year. Genotype-specific variation in postnatal, pubertal, and postpubertal growth patterns and mineral accrual explained differences in adult bone trait combinations and thus bone fragility. INTRODUCTION: Fracture risk is strongly regulated by genetic factors. However, this regulation is...
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