Article
Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength.
PLoS genetics - 1 Jan 2012
Bassett J H Duncan, Gogakos Apostolos, White Jacqueline K, Evans Holly, Jacques Richard M, van der Spek Anne H, Ramirez-Solis Ramiro, Ryder Edward, Sunter David, Boyde Alan, Campbell Michael J, Croucher Peter I, Williams Graham R
Abstract excerpt
Osteoporosis is a common polygenic disease and global healthcare priority but its genetic basis remains largely unknown. We report a high-throughput multi-parameter phenotype screen to identify functionally significant skeletal phenotypes in mice generated by the Wellcome Trust Sanger Institute Mouse Genetics Project and discover novel genes that may be involved in the pathogenesis of osteoporosis. The integrated...
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