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Article

Phenotypic characterization of epiphycan-deficient and epiphycan/biglycan double-deficient mice.

Osteoarthritis and cartilage - 1 Jan 2010

Nuka S, Zhou W, Henry S P, Gendron C M, Schultz J B, Shinomura T, Johnson J, Wang Y, Keene D R, Ramírez-Solis R, Behringer R R, Young M F, Höök M

Abstract excerpt

OBJECTIVE: To characterize the in vivo role epiphycan (Epn) has in cartilage development and/or maintenance. METHODS: Epn-deficient mice were generated by disrupting the Epn gene in mouse embryonic stem cells. Epn/biglycan (Bgn) double-deficient mice were produced by crossing Epn-deficient mice with Bgn-deficient mice. Whole knee joint histological sections were stained using van Gieson or Fast green/Safranin-O...

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Identifiers

PMID: 19932218
DOI: 10.1016/j.joca.2009.11.006
PMCID: PMC3013283

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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