Article
Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice.
Nature genetics - 1 Sept 1998
Xu T, Bianco P, Fisher L W, Longenecker G, Smith E, Goldstein S, Bonadio J, Boskey A, Heegaard A M, Sommer B, Satomura K, Dominguez P, Zhao C, Kulkarni A B, Robey P G, Young M F
Abstract excerpt
The resilience and strength of bone is due to the orderly mineralization of a specialized extracellular matrix (ECM) composed of type I collagen (90%) and a host of non-collagenous proteins that are, in general, also found in other tissues. Biglycan (encoded by the gene Bgn) is an ECM proteoglycan that is enriched in bone and other non-skeletal connective tissues. In vitro studies indicate that Bgn may function...
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