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Article

Catalytic roles of CYP2D6.10 and CYP2D6.36 enzymes in mexiletine metabolism: in vitro functional analysis of recombinant proteins expressed in Saccharomyces cerevisiae.

Biochemical pharmacology - 28 Apr 2006

Hanioka Nobumitsu, Okumura Yoshihito, Saito Yoshiro, Hichiya Hiroyuki, Soyama Akiko, Saito Keita, Ueno Kazuyuki, Sawada Jun-ichi, Narimatsu Shizuo

Abstract excerpt

Cytochrome P450 2D6 (CYP2D6) metabolizes approximately one-third of the medicines in current clinical use and exhibits genetic polymorphism with interindividual differences in metabolic activity. To precisely investigate the effect of CYP2D6*10B and CYP2D6*36 frequently found in Oriental populations on mexiletine metabolism in vitro, CYP2D6 proteins of wild-type (CYP2D6.1) and variants (CYP2D6.10 and CYP2D6.36)...

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Identifiers

PMID: 16527257
DOI: 10.1016/j.bcp.2006.01.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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