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Article

Functional characterization of CYP2B6 allelic variants in demethylation of antimalarial artemether.

Drug metabolism and disposition: the biological fate of chemicals - 1 Oct 2011

Honda Masashi, Muroi Yuka, Tamaki Yuichiro, Saigusa Daisuke, Suzuki Naoto, Tomioka Yoshihisa, Matsubara Yoichi, Oda Akifumi, Hirasawa Noriyasu, Hiratsuka Masahiro

Abstract excerpt

Artemether (AM) is one of the most effective antimalarial drugs. The elimination half-life of AM is very short, and it shows large interindividual variability in pharmacokinetic parameters. The aim of this study was to identify cytochrome P450 (P450) isozymes responsible for the demethylation of AM and to evaluate functional differences between 26 CYP2B6 allelic variants in vitro. Of 14 recombinant P450s examined...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21746968
DOI: 10.1124/dmd.111.040352

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