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Article

CYP2D6.10 present in human liver microsomes shows low catalytic activity and thermal stability.

Biochemical and biophysical research communications - 10 May 2002

Nakamura Katsunori, Ariyoshi Noritaka, Yokoi Tsuyoshi, Ohgiya Satoru, Chida Michihiro, Nagashima Kazuo, Inoue Kazuaki, Kodama Takao, Shimada Noriaki, Kamataki Tetsuya

Abstract excerpt

Comparing bufuralol 1'-hydroxylase activity among liver microsomes prepared from individuals whose CYP2D6 genotypes had been determined, we found that the activity tended to decrease depending on the number of the CYP2D6*10 allele. Pre-incubation of liver microsomes from individuals homozygous for the CYP2D6*10 allele resulted in a decrease in the enzyme activity more rapidly than those from individuals...

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Identifiers

PMID: 12051754
DOI: 10.1016/S0006-291X(02)00328-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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