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Article

TGFbeta/BMP inhibits the bone marrow transformation capability of Hoxa9 by repressing its DNA-binding ability.

The EMBO journal - 5 Apr 2006

Wang Ning, Kim Hyung-Gyoong, Cotta Claudiu V, Wan Mei, Tang Yi, Klug Christopher A, Cao Xu

Abstract excerpt

Homeobox (Hox) gene mutations and their altered expressions are frequently linked to human leukemia. Here, we report that transforming growth factor beta (TGFbeta)/bone morphogenetic protein (BMP) inhibits the bone marrow transformation capability of Hoxa9 and Nup98-Hoxa9, the chimeric fusion form of Hoxa9 identified in human acute myeloid leukemia (AML), through Smad4, the common Smad (Co-Smad) in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

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Share to Oncogene Proteins, Fusion

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Source

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Identifiers

PMID: 16525506
DOI: 10.1038/sj.emboj.7601037
PMCID: PMC1440313

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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