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Article

Complex and Context Dependent Regulation of Hematopoiesis by TGF‐β Superfamily Signaling

1 Sept 2009

Abstract excerpt

The transforming growth factor (TGF)-beta superfamily of growth factors, including the TGF-betas, activins, and bone morphogenetic proteins (BMPs), provide cells with a broad spectrum of regulatory signals through the intracellular Smad pathway. Since loss-of-function studies of a majority of the TGF-beta superfamily members result in embryonic lethality, much of our current knowledge of the TGF-beta...

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PMID: 19796233
DOI: 10.1111/j.1749-6632.2009.04569.x

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