Sox9, a key transcription factor of bone morphogenetic protein‐2‐induced chondrogenesis, is activated through BMP pathway and a CCAAT box in the proximal promoter

Abstract excerpt

Mouse embryonic fibroblasts (MEFs) can be differentiated into fully functional chondrocytes in response to bone morphogenetic protein-2 (BMP-2). The expression of Sox9, a critical transcription factor for the multiple steps of chondrogenesis, has been reported to be upregulated during this process. But the molecular mechanisms by which BMP-2 promotes chondrogenesis still remain largely unknown. The aim of the...

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