Article
Second intron of mouse nestin gene directs its expression in pluripotent embryonic carcinoma cells through POU factor binding site.
Acta biochimica et biophysica Sinica - 1 Mar 2006
Jin Zhi-Gang, Liu Li, Zhong Hua, Zhang Ke-Jing, Chen Yong-Feng, Bian Wei, Cheng Le-Ping, Jing Nai-He
Abstract excerpt
Nestin, an intermediate filament protein, is expressed in the neural stem cells of the developing central nervous system. This tissue-specific expression is driven by the neural stem cell-specific enhancer in the second intron of the nestin gene. In this study, we showed that the mouse nestin gene was expressed in pluripotent embryonic carcinoma (EC) P19 and F9 cells, not in the differentiated cell types. This...
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