Article
Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression.
Molecular and cellular biology - 1 Mar 2005
Kuroda Takao, Tada Masako, Kubota Hiroshi, Kimura Hironobu, Hatano Shin-ya, Suemori Hirofumi, Nakatsuji Norio, Tada Takashi
Abstract excerpt
The pluripotential cell-specific gene Nanog encodes a homeodomain-bearing transcription factor required for maintaining the undifferentiated state of stem cells. However, the molecular mechanisms that regulate Nanog gene expression are largely unknown. To address this important issue, we used luciferase assays to monitor the relative activities of deletion fragments from the 5'-flanking region of the gene. An...
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