Article
Identification of karyopherin-alpha 2 as an Oct4 associated protein.
Journal of genetics and genomics = Yi chuan xue bao - 1 Dec 2008
Li Xiangqun, Sun Lei, Jin Ying
Abstract excerpt
The POU domain transcription factor Oct4 is a master regulator in maintaining self-renewal and pluripotency of embryonic stem (ES) cells. To further explore the functional network of Oct4, the yeast two-hybrid system was used to search for Oct4 interacting proteins. PH domain (containing POU domain and homeodomain) of human OCT4 was used as a bait. From the human testis cDNA library, we identified a strong...
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