Article
Reciprocal Transcriptional Regulation of <i>Pou5f1</i> and <i>Sox2</i> via the Oct4/Sox2 Complex in Embryonic Stem Cells
30 Jun 2005
Abstract excerpt
Embryonic stem cells (ESCs) are pluripotent cells that can either self-renew or differentiate into many cell types. Oct4 and Sox2 are transcription factors essential to the pluripotent and self-renewing phenotypes of ESCs. Both factors are upstream in the hierarchy of the transcription regulatory network and are partners in regulating several ESC-specific genes. In ESCs, Sox2 is transcriptionally regulated by an...