Genetic characterization of the APC locus involved in familial adenomatous polyposis.

doi:10.1016/0016-5085(91)90472-w

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Article

Genetic characterization of the APC locus involved in familial adenomatous polyposis.

Gastroenterology - 1 Jul 1991

Olschwang S, Weiffenbach B, Laurent-Puig P, Melot T, Vassal A, Falls K, Salmon R J, Parc R, Strong L, Nakamura Y

Abstract excerpt

Familial adenomatous polyposis is a rare disease inherited in a Mendelian dominant fashion. It is characterized by the occurrence of more than 100 adenomatous polyps in the large bowels of affected individuals. The genetic defect responsible for adenomatous polyposis resides at a locus called APC...

Topics

Adenomatous Polyposis Coli
Chromosome Aberrations
Chromosome Disorders
Chromosomes, Human, Pair 5
Colonoscopy
DNA Probes
Female
Genetic Linkage
Genotype
Humans
Lod Score
Male

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