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Article

Oncogenic mutations of alpha-Gi2 protein are not determinant for human adrenocortical tumourigenesis.

European journal of endocrinology - 1 Aug 1995

Gicquel C, Dib A, Bertagna X, Amselem S, Le Bouc Y

Abstract excerpt

Activating mutations of G proteins, which are membrane signal transducers, have been associated recently with the development of various endocrine neoplasms. Mutations of two highly conserved codons, Arg201 and Gln227, in the alpha-subunit of the Gs protein, the adenylyl cyclase-stimulating protein, were first described in growth hormone-producing pituitary tumours. They resulted in constitutive activation of the...

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PMID: 7655640
DOI: 10.1530/eje.0.1330166

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Oncogenic mutations of alpha-Gi2 protein are not determinant for human adrenocortical tumourigenesis.PMID 7655640Read ↗

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Two G protein oncogenes in human endocrine tumors.Semantic proximity Read ↗

Activating mutation of the stimulatory G protein (gsp) as a putative cause of ovarian and testicular human stromal Leydig cell tumors.Semantic proximity Read ↗

[Endocrine tumors associated to protein Gsalpha/Gi2alpha mutations].Semantic proximity Read ↗

Absence of the previously reported G protein oncogene (gip2) in ovarian granulosa cell tumors.Semantic proximity Read ↗

G protein abnormalities in pituitary adenomas.Semantic proximity Read ↗

Rare mutations of the Gs alpha subunit gene in human endocrine tumors. Mutation detection by polymerase chain reaction—primer-introduced restriction analysisSemantic proximity Read ↗

Activating genomic alterations in the Gs alpha gene ( GNAS ) in 274 694 tumorsSemantic proximity Read ↗

A new constitutively activating mutation of the Gs protein alpha subunit-gsp oncogene is found in human pituitary tumours.Semantic proximity Read ↗

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