Oncogenic mutations of alpha-Gi2 protein are not determinant for human adrenocortical tumourigenesis.

doi:10.1530/eje.0.1330166

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Article

Oncogenic mutations of alpha-Gi2 protein are not determinant for human adrenocortical tumourigenesis.

European journal of endocrinology - 1 Aug 1995

Gicquel C, Dib A, Bertagna X, Amselem S, Le Bouc Y

Abstract excerpt

Activating mutations of G proteins, which are membrane signal transducers, have been associated recently with the development of various endocrine neoplasms. Mutations of two highly conserved codons, Arg201 and Gln227, in the alpha-subunit of the Gs protein, the adenylyl cyclase-stimulating protein, were first described in growth hormone-producing pituitary tumours. They resulted in constitutive activation of the...

Topics

Adolescent
Adrenal Cortex Neoplasms
Adult
Base Sequence
Electrophoresis
Exons
GTP-Binding Protein alpha Subunit, Gi2
GTP-Binding Protein alpha Subunits, Gi-Go
GTP-Binding Proteins
Humans
Introns

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Molecular Probes

Molecular Sequence Data

Mutation

Oncogenes

Proto-Oncogene Proteins

Source

Open in PubMed

Identifiers

PMID: 7655640
DOI: 10.1530/eje.0.1330166

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7655640-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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