Article
G protein mutations in tumours of the pituitary, parathyroid and endocrine pancreas.
Biochemical and biophysical research communications - 26 Jun 1995
Boothroyd C V, Grimmond S M, Cameron D P, Hayward N K
Abstract excerpt
A subset of growth-hormone (GH) producing pituitary adenomas harbour mutations at residues Arg201 and Gln227 of the alpha subunit of the stimulatory G protein (Gs alpha). One such mutation has been reported in a GH-producing tumour from a patient with multiple endocrine neoplasia type 1 (MEN 1) a...
Topics
- Base Sequence
- Deoxyribonucleases, Type II Site-Specific
- GTP-Binding Proteins
- Growth Hormone
- Humans
- Islets of Langerhans
- Molecular Sequence Data
- Multiple Endocrine Neoplasia Type 1
- Mutation
- Pancreatic Neoplasms
- Parathyroid Neoplasms
- Pituitary Neoplasms
- Polymerase Chain Reaction
- Sequence Analysis, DNA