Article
G protein mutations in tumours of the pituitary, parathyroid and endocrine pancreas.
Biochemical and biophysical research communications - 26 Jun 1995
Boothroyd C V, Grimmond S M, Cameron D P, Hayward N K
Abstract excerpt
A subset of growth-hormone (GH) producing pituitary adenomas harbour mutations at residues Arg201 and Gln227 of the alpha subunit of the stimulatory G protein (Gs alpha). One such mutation has been reported in a GH-producing tumour from a patient with multiple endocrine neoplasia type 1 (MEN 1) although mutations have not been reported in other tumours associated with MEN 1. We used PCR-induced restriction site...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.