Two G protein oncogenes in human endocrine tumors.

doi:10.1126/science.2116665

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Article

Two G protein oncogenes in human endocrine tumors.

Science (New York, N.Y.) - 10 Aug 1990

Lyons J, Landis C A, Harsh G, Vallar L, Grünewald K, Feichtinger H, Duh Q Y, Clark O H, Kawasaki E, Bourne H R

Abstract excerpt

Somatic mutations in a subset of growth hormone (GH)-secreting pituitary tumors convert the gene for the alpha polypeptide chain (alpha s) of Gs into a putative oncogene, termed gsp. These mutations, which activate alpha s by inhibiting its guanosine triphosphatase (GTPase) activity, are found in...

Topics

Amino Acid Sequence
Base Sequence
DNA, Neoplasm
Endocrine System Diseases
Female
GTP Phosphohydrolases
GTP-Binding Proteins
Humans
Male
Molecular Sequence Data
Mutation
Neoplasms
Oligonucleotide Probes
Oncogenes
Pituitary Neoplasms
Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 2116665
DOI: 10.1126/science.2116665

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2116665-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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