Article
Alpha-galactosidase A deficiency leads to increased tissue fibrin deposition and thrombosis in mice homozygous for the factor V Leiden mutation.
Stroke - 1 Apr 2006
Shen Yuechun, Bodary Peter F, Vargas Fernando B, Homeister Jonathon W, Gordon David, Ostenso Kristen A, Shayman James A, Eitzman Daniel T
Abstract excerpt
BACKGROUND: Factor V Leiden (FVL) is a common genetic risk factor for vascular thrombosis in humans. Fabry disease, an X-linked lysosomal storage disorder attributable to alpha-galactosidase A (GLA) deficiency, is associated with premature vascular events that may be thrombotic in nature. METHODS: To examine a potential interaction between FvL and Gla deficiency in vivo, we analyzed tissue fibrin deposition in...
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