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Article

Effects of factor IX or factor XI deficiency on ferric chloride-induced carotid artery occlusion in mice.

Journal of thrombosis and haemostasis : JTH - 1 Apr 2005

Wang X, Cheng Q, Xu L, Feuerstein G Z, Hsu M-Y, Smith P L, Seiffert D A, Schumacher W A, Ogletree M L, Gailani D

Abstract excerpt

Factor XI (FXI) and factor IX (FIX) are zymogens of plasma serine proteases required for normal hemostasis. The purpose of this work was to evaluate FXI and FIX as potential therapeutic targets by means of a refined ferric chloride (FeCl(3))-induced arterial injury model in factor-deficient mice. Various concentrations of FeCl(3) were used to establish the arterial thrombosis model in C57BL/6 mice. Carotid artery...

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Identifiers

PMID: 15733058
DOI: 10.1111/j.1538-7836.2005.01236.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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