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Article

Effects of Disruption of The Plasminogen Gene on Thrombosis, Growth, and Health in Mice

1 Nov 1995

Abstract excerpt

BACKGROUND: Circumstantial evidence suggests that the plasminogen/plasmin system plays a role in many biological processes, including hemostasis, cell migration, and development. METHODS AND RESULTS: The in vivo function of the plasminogen/plasmin system was studied by generation of plasminogen-deficient (Plg-/-) mice. Inactivation of the murine plasminogen-gene (Plg) was achieved by replacing, via homologous...

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Identifiers

PMID: 7586361
DOI: 10.1161/01.cir.92.9.2585

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