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Article

Thrombotic phenotype of mice with a combined deficiency in plasminogen activator inhibitor 1 and vitronectin.

Journal of thrombosis and haemostasis : JTH - 1 Oct 2005

Koschnick S, Konstantinides S, Schäfer K, Crain K, Loskutoff D J

Abstract excerpt

OBJECTIVE: The role of vitronectin (VN) in thrombosis is not fully understood, primarily because this adhesive glycoprotein not only stabilizes plasminogen activator inhibitor 1 (PAI-1) and thus protects fibrin from premature lysis, but also because it binds to platelet integrins and may influence platelet aggregation. The absence of quantitative approaches to characterize the thrombi formed in animal models...

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PMID: 16194205
DOI: 10.1111/j.1538-7836.2005.01479.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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